### Dosing CrCl > 80: 3 g q 4-6 h. CrCl 80-50: 3 g q 4 - 6 h. CrCl 50-10: q 6 - 8 h. CrCl < 10: 2 g q 12 h. Hemodialysis: 3 g then 2 g q 12 h. Peritoneal dialysis: 3 g q 12 h. ### Important side effects Anaphylaxis, coagulation abnormalities; bleeding time and platelet aggregation, convulsions, hypersensitivity reactions, hypokalemia, rash, and thrombophlebitis. ### Important drug interactions ### Rants and Screeds A drug of historical interest, it is not sold in the US except combined with clavulanic acid. ### Pearls ### Treatment of choice ### Use for Guess if you want half-assed gram-negative penicillin, I suppose you could use this. [[Arthritis]], [[cellulitis]], [[empyema]], endometritis, eye infections, gynecologic infections, Iintraabdominal infections, neutropenic fever, [[osteomyelitis]], [[pneumonia]], [[Sepsis and Bacteremia]], [[sinusitis]], surgical prophylaxis, and [[Cystitis]]. ### Don't use for ### Class Penicillin.