### Dosing CrCl > 80: 200-400 mg po q 12 - 24 h. CrCl 80-50: 200-400 mg po q 12 - 24 h. CrCl 50-10: 200-400 mg po q 12 - 24 h. CrCl < 10: 200-400 mg po q 12 - 24 h. Hemodialysis: 200-400 mg po q 12 - 24 h. Peritoneal dialysis: 200-400 mg po q 12 - 24 h. ### Important side effects Abdominal pain, anaphylaxis (rare), hepatotoxicity (rare), irritation, pruritus and stinging (cream), nausea, vomiting, pruritus, and reduced testosterone (po doses of 800 mg/day or more). ### Important drug interactions Acenocoumarol, alfuzosin, alosetron, aluminum carbonate, basic, aluminum hydroxide, aluminum phosphate, amlodipine, amprenavir, anisindione, aprepitant, aripiprazole, astemizole, atorvastatin, benzodiazepines, bexarotene, budesonide, calcium, carbamazepine, cerivastatin, cilostazol, cimetidine, cinacalcet, cisapride, conjugated estrogens, cyclosporine, darifenacin, delavirdine, dicumarol, didanosine, dihydroxyaluminum aminoacetate, dihydroxyaluminum sodium carbonate, dofetilide, donepezil, dutasteride, eletriptan, ergot derivatives, erlotinib, [[erythromycin]], esomeprazole, esterified estrogens, estradiol, estriol, estrone, estropipate, eszopiclone, famotidine, felodipine, fentanyl, gefitinib, imatinib, indinavir, irinotecan, [[isoniazid]], isradipine, lansoprazole, levomethadyl, lovastatin, magaldrate, magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, methylprednisolone, nevirapine, nicardipine, nifedipine, nisoldipine, nizatidine, omeprazole, pantoprazole, phenindione, phenprocoumon, pimozide, pioglitazone, prednisolone, prednisone, quetiapine, quinidine, rabeprazole, ranitidine, reboxetine, [[rifampin]], rifapentine, ritonavir, roxatidine, saquinavir, sildenafil, simvastatin, sirolimus, sodium bicarbonate, solifenacin, tacrolimus, tadalafil, terfenadine, tolbutamide, tolterodine, trazodone, tretinoin, [[Trimetrexate]], vardenafil, warfarin, and zolpidem. ### Rants and Screeds ### Pearls Acid dependent absorption. ### Treatment of choice *Paracoccidiodes* *brasiliensis*. ### Use for For many of these, the indications occurred before the newer and often better agents. [[Acne]], *[[Blastomyces]]* *dermatiditus*, blepharitis, [[Candida]] - chronic mucocutaneous/ cutaneous/disseminated/esophageal/oral/urinary/vaginal, *[[Chromomycosis]]* systemic infections, *[[Coccidioides]]* *immitis*, *[[Cryptococcus]]* *neoformans*, cutaneous dermatophyte infections, dermatitis - seborrheic, *[[Histoplasma]]*, Leishmaniasis, *Paracoccidiodes*, prostatic carcinoma, *[[Pseudallescheria]]* *boydii*, and *[[Sporothrix]]*. ### Don't use for ### Class