### Tags [[tags/POIS]], [[tags/SAM-e]], [[tags/dietary interventions]], [[tags/food sensitivities]], [[tags/immune competence]], [[tags/methylation]], [[tags/quality of life]], [[tags/supplementation]] ### POIS Case Study - tteezzkk #### 1. **Summary of POIS Experience and History** The individual has experienced POIS for over 6 years, characterized by severe post-orgasmic symptoms including fatigue, brain fog, muscle weakness, irritability, anxiety, and social anxiety. Symptoms typically onset within 30 minutes to 2 hours post-orgasm and persist for 3-5 days, with gradual improvement. Over time, the condition has remained stable, with no progression or development of new symptoms. The individual has explored a wide range of treatments, including dietary changes, supplementation, and lifestyle modifications, achieving significant symptom reduction and improved quality of life. #### 2. **Key Symptoms and Their Patterns** - **Primary Symptoms**: Severe fatigue, brain fog, muscle weakness, irritability, anxiety, mood disturbances, and social anxiety. - **Onset and Duration**: Symptoms appear within 30 minutes to 2 hours post-orgasm and last 3-5 days. - **Triggers and Variability**: Symptom severity is influenced by orgasm frequency, stress levels, poor sleep, and seasonal changes. - **Abstinence Effects**: Increased energy and motivation to seek intimacy during abstinence, contrasting with a more relaxed but less driven state post-ejaculation. - **Food Sensitivities**: Improved but still present, with reactions affecting motivation, energy, and social fluency the next day, especially when consuming problematic foods at night. #### 3. **Attempted Treatments and Their Effectiveness** - **Dietary Changes**: - Elimination of processed foods, sugar, and gluten; increased intake of anti-inflammatory foods. - Animal-based diet (200-300g red meat, 2-3 eggs daily) showed significant symptom reduction. - Low-histamine diet provided moderate relief. - **Supplementation**: - **Omega-3 fatty acids, magnesium, zinc, vitamin D**: Reduced inflammation and improved overall symptoms. - **Raw garlic and fenugreek**: Taken before and after orgasm, significantly reduced symptoms. - **SAM-e (S-adenosylmethionine)**: Achieved near-complete remission, with symptom recurrence upon discontinuation. - **Vitamin B complex (Nature’s Own 150 B Forte)**: Improved chronic mental symptoms like brain fog. - **Choline**: Recommended for its role in neurotransmitter synthesis and cognitive function. - **Medications**: - **Antihistamines (Zyrtec)** and **NSAIDs**: Provided partial relief. - **Lifestyle Modifications**: - Regular exercise, stress management (meditation, yoga), adequate sleep, and hydration were crucial for symptom management. - **Methylation Support**: - **SAM-e**: Highly effective in reducing symptoms, with significant improvement reported. - **Co-factors**: B vitamins (B12, folate, B6), choline, TMG, methionine, and L-theanine were recommended to support methylation pathways. - **Immune Competence Therapy**: - **AHCC**: Used as part of an antiviral approach, based on the hypothesis that latent viral infections may contribute to POIS. #### 4. **Current Status** - **Cured**: False - **Current Status**: Significant improvement in symptoms (up to 95% reduction), with only mild tiredness, spaciness, and slight anxiety remaining. The individual no longer requires SAM-e or other supplements, with maintained symptom relief and improved quality of life. #### 5. **Relevant Medical Test Results or Biomarkers** - **Vitamin B12 and Folate Levels**: Normal prior to supplementation, yet B complex still provided significant symptom relief. - **Methylation Deficiency**: Severe symptoms (e.g., brain fog, food sensitivities) linked to methylation dysfunction, resolved with SAM-e. - **Allergy Testing**: Dr. Jia Yin’s research ruled out IgE-mediated semen allergy as a primary cause of POIS in a studied case. #### 6. **Identified Triggers or Correlations** - **Triggers**: Orgasm frequency, stress levels, poor sleep, seasonal changes, and food sensitivities. - **Correlations**: Anti-inflammatory, immune-modulating, and methylation pathways (e.g., SAM-e, B vitamins) may play key roles in POIS pathophysiology. #### 7. **Quality of Life Impact** - **Pre-Treatment**: Severe symptoms lasting several days post-orgasm significantly impaired daily functioning, mental clarity, and social interactions. - **Post-Treatment**: Dramatic improvement in symptoms, with sustained relief after resolving methylation deficiency. The individual experiences minimal post-ejaculation symptoms and improved quality of life. TAGS: POIS, methylation, SAM-e, dietary interventions, supplementation, immune competence, food sensitivities, quality of life CURED: False RELEVANCE_SCORE: 9