### Tags [[tags/Buspirone]], [[tags/Fluoxetine]], [[tags/NSAID subtype]], [[tags/POIS]], [[tags/Parkinson's Disease]], [[tags/brain fog]], [[tags/dopaminergic excitotoxicity]], [[tags/inflammatory pathways]], [[tags/prostaglandins]], [[tags/psychiatric treatment]] ### POIS Case Study - kasra #### Summary of POIS Experience and History Kasra has experienced POIS for over 7 years, characterized by severe cognitive and physical symptoms following orgasm. The condition significantly impacted their quality of life, leading to extensive consultations with specialists, including urologists and immunologists, before finding relief through psychiatric treatment. Kasra's case is notable for its unique symptom profile, comorbid conditions (e.g., early-onset Parkinson's Disease, inflammatory disorders), and the eventual success of a psychiatric medication regimen. #### Key Symptoms and Patterns - **Cognitive Symptoms**: Severe brain fog, short- and long-term amnesia, slurred speech, hypersensitivity to sound, and head "stuffiness." - **Physical Symptoms**: Thrumming of middle ear muscles, headache, nausea, fatigue, sleep disturbances (light sleep, sleeplessness, vivid dreams), scalp pimples, and crawling sensations on the scalp and face. - **Onset and Duration**: Symptoms begin within 30 minutes of orgasm, peak over 3 days, and resolve over 5-7 days. Cumulative ejaculations and intense orgasms worsen symptoms. - **Comorbid Conditions**: Early-onset Parkinson's Disease, restless legs syndrome, self-diagnosed hypoglycemia, and inflammatory disorders (tendonitis, bursitis, sinusitis). #### Attempted Treatments and Effectiveness - **Effective Treatments**: - **Ibuprofen (400-800mg)**: Taken 20 minutes before arousal, it reduced symptom severity by 80-90%, likely by inhibiting prostaglandin synthesis. - **Fluoxetine (Prozac) 80mg + Buspirone 20mg**: After 3 months, this psychiatric regimen completely resolved brain fog and itchy eyes, significantly improving quality of life. - **Ineffective Treatments**: Antihistamines, Niacin, B-12, Vitamin C, multivitamins, Tylenol (before orgasm), diet, exercise, and alcohol provided no relief. Tylenol before bedtime helped with hypersensitivity and sleep. #### Current Status Kasra reports being **cured** of POIS symptoms after 3 months on the psychiatric medication regimen. Their quality of life has significantly improved, with no recurrence of brain fog or itchy eyes. #### Relevant Medical Test Results or Biomarkers - No specific biomarkers were identified, but the case suggests a potential link between POIS and **prostaglandin-mediated inflammation**, **dopaminergic excitotoxicity**, and **brain biochemistry imbalances**. - Comorbid conditions (Parkinson's Disease, inflammatory disorders) hint at underlying inflammatory or autoimmune mechanisms. #### Identified Triggers or Correlations - **Triggers**: Orgasm, cumulative ejaculations, and intense arousal periods. - **Correlations**: Hypersexuality, prolonged arousal, and CNS stress may exacerbate symptoms. Coffee may decrease symptom duration but could worsen CNS stress. #### Quality of Life Impact Before treatment, POIS severely impaired Kasra's cognitive function, sleep, and daily activities. The condition caused significant distress and necessitated lifestyle adjustments. After successful treatment, Kasra reports a dramatic improvement in quality of life, with no residual symptoms. TAGS: POIS, NSAID subtype, brain fog, inflammatory pathways, dopaminergic excitotoxicity, psychiatric treatment, Fluoxetine, Buspirone, Parkinson's Disease, prostaglandins CURED: true RELEVANCE_SCORE: 9