### Tags [[tags/Coimbra Protocol]], [[tags/autoimmune]], [[tags/carnivore diet]], [[tags/environmental toxins]], [[tags/gut health]], [[tags/testosterone]], [[tags/vitamin D]] ### POIS Case Study - JohnJames #### Summary of POIS Experience and History JohnJames has been managing POIS for several years, experimenting with various dietary and supplementation strategies to alleviate symptoms. His journey includes trials of a carnivore diet, high-dose vitamin D supplementation, and exploration of gut health and autoimmune theories. His symptoms have shown partial improvement but remain unresolved. #### Key Symptoms and Patterns - **Symptom Timeline**: Symptoms are milder on day 1, peak on day 2, and gradually taper off over subsequent days. - **Skin Reactions**: Improved overall skin health (clearer skin, reduced dandruff and acne) but severe, painful acne localized to the skin around the penis, potentially linked to semen contact. - **General Symptoms**: Reduced severity and faster recovery time from POIS episodes, but symptoms persist. #### Attempted Treatments and Effectiveness - **Carnivore Diet**: Significant improvements in energy levels, skin health, and mood. Symptom severity reduced but not eliminated. - **High-Dose Vitamin D**: Increased libido, improved emotional responsiveness, and more restorative sleep. Anecdotal success with one-time doses of 30,000-50,000 IU. - **Gut Health Focus**: Suspected gut microbiome connection, with treatments targeting gut health (antibiotics, antifungals, dietary changes) showing some promise. #### Current Status JohnJames is not cured but has experienced notable improvements in symptom severity and recovery time. He continues to follow a carnivore diet and high-dose vitamin D supplementation. #### Relevant Medical Test Results or Biomarkers - **Vitamin D Levels**: High-dose supplementation (20,000+ IU/day) with cofactors like magnesium. - **Parathyroid Hormone Levels**: Potential relevance in the context of the Coimbra Protocol. - **Gut Health**: Suspected leaky gut syndrome and microbiome dysbiosis. #### Identified Triggers or Correlations - **Dietary Triggers**: Exclusion of butter, fruits, and vegetable oils on the carnivore diet. - **Environmental Toxins**: Hypothesis involving mercury and aluminum as potential contributors to POIS. - **Testosterone Levels**: Paradoxical effects where activities that boost testosterone worsen symptoms, while sleep deprivation (which lowers testosterone) improves symptoms. #### Quality of Life Impact JohnJames reports significant improvements in energy levels, skin health, and mood, leading to a better overall quality of life. However, the persistence of POIS symptoms continues to impact his daily functioning and well-being. TAGS: carnivore diet, vitamin D, gut health, autoimmune, testosterone, environmental toxins, Coimbra Protocol CURED: false RELEVANCE_SCORE: 9