<< [[SuperHuman ⁰²- Liz Parrish - Becoming GMO, Gene Therapy, BioViva| LAST NOTE]] | [[Super Human 2005 ⁰⁰- MOC|ALL NOTES]] | [[SuperHuman ⁰⁴ -Johan Juhin- Mavatar -Digital Twin| NEXT NOTE]]>> **📅 Date:** ➤ ⌈[[2025-06-09-Mon〚 📘³ Corporate Issuers ▪Mental Health, Psychedelics & Immunology ▪Digital Twin 〛]]⌋ **👤 Who**：David Barry Jr, Ron, Joe Betts Lacroix, Lêfo, and David Furman **💭 What:** ➤ Longevity, Immunology, Psychedelics, Functional Health, AI Acceleration ➤ #👾/Comment Interesting point of the use of psychedelics .. recalls our interview with Joao, whose fund invested in the mental sector **👀 Snap:** ➤ **Accelerating the aging process in female blood** (likely to simulate aging faster, for research or intervention purposes) - David Furman - [Space Medicine at the Buck](https://www.buckinstitute.org/blog/space-medicine-at-the-buck/?utm_source=chatgpt.com) ➤ Immune System Tracking as a Sensory System (免疫系统追踪机制) - Dr. David Furman ➤Partial Cellular Reprogramming (部分细胞重编程) - Joe Betts-LaCroix ⇩ 🅻🅸🅽🅺🆂 ⇩ **🏷️ Tags**: #🌿/LG **🗂 Menu**: ⌈[[Super Human 2005 ⁰⁰- MOC| SuperHuman 2025]]⌋ ⌈[[✢ M O C ➣ 06 ⌈J U N - 2 0 2 5⌉ ✢|2025 - J U N- MOC]]⌋ ⌈[[✢ L O G ➢ 06 ⌈J U N - 2 0 2 5⌉ ✢|2025 - J U N - LOG]]⌋ #👾/Private ------➤ ⌈[[Albert Hofmann-LSD]]⌋ ------➤ ⌈[[Partial Cellular Reprogramming（部分细胞重编程]]⌋ ------➤ ⌈[[The HW Project Research List]]⌋ #👾/Private **🌐 Related Watch List**: 1. Joao Barbosa Da Silva -[Brain Health Investor: Why Psilocybin Could Be the Next Big Thing](https://www.youtube.com/watch?v=cikmng-4B_g) 2. Dr. Lee Hood ▶️ [The Human Genome Project](https://youtu.be/-opIj-7mj_U?si=lkufKyz4Sh8yHOpG) 3. Dr. Jennifer Garrison ▶️ [The Truth About Female Ageing: Dr Jennifer Garrison](https://www.youtube.com/watch?v=tG_cJZWVxG8) 4. Dr. Ashley Webb ▶️ [Inside The Lab Detecting Alzheimer's Before Symptoms](https://youtu.be/TEjoAlmR22E?si=cvrI5ZxQXFH97qnu) --- ## 🧑‍⚕️ Speakers & Roles - **Jr Ron (Founder, RMR Sciences)** - Mission: End fentanyl overdose in America. - Immunotherapies taken 1-2 times/year. - Previous: MindMed Founder, first psychedelic biotech IPO, LSD Phase III trials for anxiety. - **Joe Betts-LaCroix (CEO, Retro Biosciences)** - Mission: Extend healthy human lifespan by 10 years. - Funded by Sam Altman ($180M). - Team of 66 scientists. - Focus: Partial reprogramming, autophagy, clinical trials. - **David Furman (Head, Stanford Immunodomes & Professor, Buck Institute)** - Focus: Human immunology, AI/ML, functional longevity. - Startups on aging diagnostics, inflammation, microplastics. - Collaboration: NASA, WHO for low/middle income diagnostics. >[!info] HumanWare Interview -With the scientists Form the BUCK Institute >1. Dr. Lee Hood ▶️ [The Human Genome Project](https://youtu.be/-opIj-7mj_U?si=lkufKyz4Sh8yHOpG) >>![[IMG_8952.jpeg|#left|200]] >2. Dr. Ashley Webb ▶️ [Inside The Lab Detecting Alzheimer's Before Symptoms](https://youtu.be/TEjoAlmR22E?si=cvrI5ZxQXFH97qnu) >>![[IMG_8962.jpeg|#left|200]] >3. Dr. Jennifer Garrison ▶️ [The Truth About Female Ageing: Dr Jennifer Garrison](https://www.youtube.com/watch?v=tG_cJZWVxG8) >>![[IMG_8967.jpeg|#left|200]] >4. Dr. Pankaj Kapahi ▶️ Coming Soon --- ## 🔑 Key Topics & Insights ### 1️⃣ What Does Longevity Mean? - **Furman:** Functional health span — maintaining cognition, movement, purpose into advanced age. - **Joe:** Brain health as primary lever; aging involves multiple systems. - **JR:** Mental clarity shapes decision-making; brain longevity is crucial. --- ### 2️⃣ Psychedelics & Longevity - 12% lower diabetes risk; 23% lower heart issues for those who've used psychedelics (Karolinska & Imperial College study). - More clinical trials needed to confirm causality. - *Anecdote:* Albert Hoffman (LSD inventor) lived to 102, allegedly microdosing LSD last 30 years. > 🧪 **Regulatory limitation:** FDA requires targeting specific diseases for trials. >[!info] HumanWare Interview -Recalls to the conversation with Joao Psychedelics as an investment... >▶️ [Brain Health Investor: Why Psilocybin Could Be the Next Big Thing](https://www.youtube.com/watch?v=cikmng-4B_g) ![[IMG_8951 1.jpeg|#left|300]] --- ### 3️⃣ Misconceptions in Longevity Research - **Furman:** Aging clocks like epigenetic clocks are not yet validated to predict lifespan. - **Joe:** Oversimplification — aging is multi-causal, no "one cause" of aging. - **JR:** Need stronger clinical evidence over marketing claims. --- ### 4️⃣ Mental Longevity & Addiction - JR overcame addiction via psychedelics. - Shift mindset toward becoming "superhuman." - Health consciousness entering cultural Zeitgeist. --- ### 5️⃣ Immune System as a Sensory System - Immune system responds to all environmental inputs: diet, sleep, exercise, pollution. - *Inflammatory Aging Clock* developed to monitor systemic low-grade inflammation. - Chronic inflammation affects organs, increases risks for cancer, CVD, Alzheimer’s. > 🔬 Biomarker tracking via blood tests (future: digital tracking goals). --- ### 6️⃣ Upcoming Near-Term Breakthroughs - **Retro Biosciences (Joe):** - Internal partial reprogramming program. - Phase 1 autophagy trial in Australia (later this year). - **Furman:** - ARPA-H application to fast-track diagnostics to FDA. - New product: microgravity-induced accelerated blood aging (launching August). - **JR:** - MindMed LSD & Compass psilocybin trials reading out in next 12 months. - Immunotherapy project blocking fentanyl access to brain. --- ### 7️⃣ Personal Philosophies on Success & Hope - **Joe:** Extend healthy lifespan by 10 years for healthiest 50% of population. - **Furman:** Democratize diagnostics globally (WHO collaborations). - **JR:** Mental reset through psychedelics is crucial for long-term well-being. - **AI Impact (Joe):** Scientists 2x more productive post-ChatGPT; expecting 10x productivity gains. --- ## 🔬 Summary Takeaways - Focus on *functional health* > lifespan numbers. - Psychedelics = promising avenue for mental longevity. - Brain, immune system & inflammation = key aging levers. - Partial reprogramming shows powerful rejuvenation signals. - Democratizing access to diagnostics critical for global health equity. - AI accelerating research dramatically — new velocity for science.