# 1.6 Resveratrol and Magnesium > [!TLDR] Grocery List (90 day supply of full dose) > - [ ] 250g Resveratrol Powder $71 [bulksupplements.com](https://www.bulksupplements.com/products/resveratrol-pure?variant=32133451251823) > - [ ] Magnesium chloride topical spray $8 [Fullscript](https://us.fullscript.com/o/care-center/products/U3ByZWU6OlByb2R1Y3QtODM0MDM=/U3ByZWU6OlZhcmlhbnQtOTk5OTI=?query=%22magnesium%20spray%22) # Magnesium Apply magnesium spray liberally once daily. The best time to apply it is after a shower. Transdermal (through the skin) absorption is slow and steady, giving the body time to use the magnesium and put it where it needs to go. As always, I recommend starting with a low dose and increasing as tolerated. Starting magnesium and/or phosphate can improve glucose uptake and glycogen synthesis. Experiencing symptoms that resemble hypoglycemic events or diabetic "hangry" mood alterations may indicate more dietary carbohydrates are needed. The spray can dry on the skin and become irritating. Re-wetting it with water can help and improve absorption further. # Resveratrol Start taking resveratrol at 50 mg three times daily, 30 minutes before breakfast, lunch and dinner. Increase to a goal dose of 500 mg three times daily. > [!Warning] Normal vs trans-resveratrol > If you are using trans-resveratrol, reduce the dose by half. > [!NOTE] Mechanism > Resveratrol, found in grapes and red wine, is added here because it slows pyruvate dehydrogenase (PDH) kinase, protecting against lactic acid buildup as glycolysis bottlenecks are removed. > > Glycolysis = breaking down glucose into pyruvate, the molecule that can be used to feed aerobic or anaerobic metabolism > > Correcting magnesium deficiency increases the amount of glucose that can undergo glycolysis. This makes more pyruvate available for the cell to use for energy. We need as much of that pyruvate as possible to be moved into the mitochondria and used for aerobic metabolism because the alternative, anaerobic metabolism, creates a lot of lactic acid as a byproduct. > > Pyruvate dehydrogenase (PDH) is the regulator enzyme that decides how the pyruvate will be used. If the PDH is "on" it will sent pyruvate for aerobic metabolism (citric acid cycle and oxidative phosphorylation). If PDH is "off", pyruvate stays in the cytosol and is turned into lactate. > > PDH kinase is the switch that turns PDH off. By slowing down PDH kinase, we keep PDH on and maximize how much pyruvate undergoes oxidative phosphorylation, reducing lactic acid buildup.