# Antidepressants --- **antidepressants** are a type of [[medicine]] that It does take 2-4 four weeks to get the benefits, but they'll feel the adverse reactions right away. If they can push through the GI distress they do tend to diminish and you get the benefits. ## Mechanism of Action ## Contraindications ## Adverse Reactions >[!warning] Black Box Warning >black box warnings for **antidepressants**? increased **suicidal ideation** and behavior in people under 24 years - The two main side effects, and the reasons that people most often stop taking these are: - GI distress - sexual dysfunction ## Examples [[SSRIs]] [[SNRIs]] - venlafaxine discontinuation syndrome tends to be worse with this one [[NDRI]] Older antidepressants that are less commonly used [[MAOIs]] [[Tricyclic antidepressants]] • Amitryptyline, nortriptyline • Less commonly used. • Sometimes used in low doses as a sleep aid. Other topics in antidepressant medications • Abilify- 3rd generation antipsychotic. Often used as an adjunct in treatment of depression. • Trazodone- Commonly prescribed as a sleep aid. • Duloxetine (SNRI)- Often used for pain as well as depression. ___