# SIADH --- **SIADH** stands for **Syndrome of Inappropriate Antidiuretic Hormone Secretion**, and it's a condition where overproduce [[antidiuretic hormone]], which means the body retains way too much water by drastically reducing the formation of urine. This is bad for a couple reasons, but one is that it which puts you at risk for dilutional [[hyponatremia]]. ## Causes SIADH is often non-endocrine in origin, usually due to a [[brain]] or [[spinal cord]] condition affecting the pituitary gland. Sometimes it's caused by an ectopic production of ADH from malignant tumors or [[lungs|lung]] conditions. Some medications can also cause SIADH, such as vincristine and tricyclic [[antidepressants]]. ## Signs & Symptoms - decreased urine output and also *concentrated* urine with high specific gravity - water retention - [[hyponatremia|dilutional hyponatremia]] - bounding pulse - crackles in lungs ## Treatment The goal of treatment for SIADH is to fix the underlying cause such as treating the cancer if it exists. To treat the symptoms of SIADH you can: - implement a fluid restriction - give hypertonic saline - to treat any dilutional hyponatremia - [[diuretics|furosemide]] ___