![[Pasted image 20220902092755.png]] The sodium potassium pump pumps three Na+ ions out into the extracellular fluid for every two K+ ions it pumps in. This process takes ATP because it moves against the concentration gradient and leads. This system can lead to a negative net charge inside the cell compared to the outside. ### ⛽Sodium Potassium Pump in Neuron signaling This is particularly critical in [[Neuron signaling]] which requires the charge differentials to start action potentials after depolarization. In fact, without the ability to transport sodium outside of the cell, you would die. ### 🐡Death by Puffer Fish Puffer fish have a toxin in their ovaries which block sodium channels. Some cultures see puffer fish as a delicacy making it crucial that chefs remove the ovaries correctly during preparation. Otherwise, people won't be able to breathe.